H

REACH THE WORLD.

 

Groupe PARIMA

is a Contract Development and Manufacturing Organization (CDMO), established in 1994. For over 20 years, we have developed an expertise in the development and manufacturing of non-sterile liquids, suspensions and semi-solid drugs, homeopathic products, natural health products and medical devices. We work hand-in-hand with our clients to customize our services to meet their needs. From full turn-key to highly collaborative development projects, we can adapt to fit your operational requirements. We have been favorably inspected by the EMA, FDA and Health Canada, and manufacture products for markets around the globe.

 

 


Product Development Services

PDS

With dedicated project managers with expertise in developing and supporting regulatory approval of a wide range of products (IND, NDA, 505(b)(2), ANDA, cosmetic, OTC), Groupe Parima can meet your product development and transfer needs. Based on the status of your project, our experts in formulation development, process scale-up, analytical method development & validation and packaging, will see your product through commercial validation, providing you with a single point of contact for all steps of the project.

Expertise in formulation development

Liquids, Suspensions, Creams, Lotions, Gels, Ointments, Pastes, Handling of low flash point products and processes

Different stages of activities

  • Basic formulation
    • De novo formulation
    • Reverse engineering
    • Equivalence to reference drug products
    • Raw material sourcing for cGMP productions
    • Effectiveness and stability of formulations
    • Identification of critical characteristics
    • Selection of packaging components
  • Process development
    • Laboratory, pilot, cGMP clinical trial materials and cGMP commercial scale
    • Development and optimization using QbD
    • Documentation and reporting to support regulatory filings
    • Development of packaging process (primary and secondary)
    • Stability and transportation studies
  • Supply of clinical and pre-clinical lots
    • Small scale productions for pre-clinical studies
    • Supply of cGMP clinical material (Phases I-III)
    • Excess product stored on-site for future studies
    • Stability studies
    • Customized packaging and labeling
  • Commercial validation
    • Artwork preparation
    • Sourcing of all commercial packaging material
    • Complete manufacturing, holding, packaging and cleaning validation
    • Stability studies

 

Commercial Manufacturing Services

CMS

Groupe PARIMA offers contract manufacturing and packaging services to clients throughout the world. With products manufactured for markets located on all five continents, we have a global reach. Our services levels include our most popular full turn-key service, as well as other arrangements for client who prefer to provide some of the material.

Currently, Groupe PARIMA produces a wide range of commercial products, with the following applications:

  • Angina pectoris (oral spray)
  • Acne vulgaris (cleanser, towelette, gel)
  • Constipation (oral liquid)
  • Cough and fever treatments (oral liquid)
  • Dermatitis and eczema (cream, lotion, ointment)
  • Dry hands (lotion, cream)
  • Erectile dysfunction (cream)
  • Fungal Infections (liquid)
  • Headaches (oral liquid)
  • Hemorrhoids (cream)
  • Herpes simplex infection (ointment)
  • Joint inflammation (oral suspension)
  • Musculoskeletal pain (cream)
  • Sunscreen products (SPF 30-50+, cream, lotion)



Manufacturing

M

Our 66,000 square feet modern facility is equipped with a wide range of manufacturing equipment that allows us to handle all types of semi-solids, liquids and suspensions.

Spread over four commercial manufacturing suites, we can manufacture your drug products on the following scales:

  • 5 kg to 2,500 kg: Creams, lotions, gels, ointments, high viscosity pastes and high-SPF sunscreen products
  • 5 kg to 4,000 kg: liquids, syrups, suspensions
  • Fully jacketed tanks that allow temperature control between 2 ºC and 95 ºC
  • Tanks are equipped with sweep, counter-sweep and homogenizers
  • Secondary manufacturing equipment is also available (e.g., Lightnin mixers, Rotosolver, Colloid Mills, APV)

In addition to these capabilities, we have a dedicated explosion-proof manufacturing suite designed specifically to handle manufacturing of low-flash points mixtures (e.g., high-alcohol content gels and liquids).

  • 1D1 rated room
  • Inert gas blanketing
  • Amber lighting for light-sensitive products
  • Manufacturing volumes of 5 kg to 1,600 kg

Packaging

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Groupe PARIMA has a dedicated packaging suite equipped with 11 different packaging lines to meet your needs for all types of primary and secondary packaging. Depending on annual volumes projected, we can offer different levels of automation to provide you with the most cost-effective options for your product.

  • Bottles and Jars 5 ml-1,000 ml - plastic and glass
  • Sprays (including metered-dose) 5 mL -150 mL
  • Tubes 3 mL - 350 mL plastic, laminate and metal
  • Syringe (non-sterile applicators)
  • Towelettes 1 mL – 15 mL
  • Sachets 1 mL - 15 mL
  • Bag-on valves

Analytical Services

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Our laboratory is fully equipped to perform all release and stability tests. From state-the-art LCMS analyses to microbiology and more routine physical tests, Groupe PARIMA can perform a wide range of analyses to fit your needs. Our chromatography instruments are all powered by the Empower 3 software, and all analytical results are kept in our LIMS system.

Groupe PARIMA has on-site stability chambers to perform all typical ICH stability tests, including Zone IV-b condition and low temperature (2-8°C for cold-chain products).

Analytical chemistry equipment

  • Agilent and Waters HPLCs and UPLCs
  • Agilent GC with Head-Space
  • Waters LCMS detector
  • Laser based particle sizing (Mastersizer 3000)
  • Laser based droplet sizing (nasal and oral sprays, Spraytech)
  • Shimadzu TOC
  • Agilent dissolution apparatus
  • IR and UV spectrometers
  • Viscometers and rheometers
  • Microscope
  • Fully equipped for other physical tests

Microbiology tests performed on-site

  • Total aerobic count (USP<61>)
  • Yeast and mold (USP<61>)
  • Specific organisms (USP<62>)
  • Microorganism identification
  • Antimicrobial effectiveness test (USP<51>)

Stability conditions

  • Standard (25 °C/65% RH)
  • Moderate (30 °C/65% RH)
  • Accelerated (40 °C/75% RH)

Zone IV-B

  • 30 °C/75% RH

Cold-chain products

  • 2-8 °C

About us

A

COMPANY
 

Groupe PARIMA is a Contract Development and Manufacturing Organization (CDMO), established in 1994. For over 20 years, we have developed an expertise in the development and manufacturing of non-sterile liquids, suspensions and semi-solid drugs, homeopathic products, natural health products and medical devices. We work hand-in-hand with our clients to customize our services to meet their needs. From full turn-key service to highly collaborative development projects, we can adapt to fit your operational requirements.

OUR CLIENTS
 

With products manufactured for markets located on all five continents, we have a global reach. Our client base ranges from small startup and virtual companies to large pharmaceutical companies headquartered around the globe. We have been favorably inspected by the EMA, FDA and Health Canada.

OUR MANGEMENT TEAM
 


The management team is supported by a staff of professionals with a wide range of expertise and experience including chemists, biochemists, microbiologists, engineers, and highly qualified operators.


Career

C

Please send your CV to this email.

info@groupeparima.com


Certifications

C

FDA Registration Number : 3003773810
NDC Labeler Code : 65179
Health Canada Drug Establishment Licence  : 100062-A
Licenced by Health Canada to produce NPN and Homeopathic products
Generic Drug User Fee Amendment (GDUFA) Compliant


Contact

C
Groupe Parima inc.
4450, rue Cousens
Saint-Laurent QC  H4S 1X6
Canada

 



For general inquiries
+1.514.338.3780
info@groupeparima.com

New Business Inquires or Projects+1.514.338.3780
bd@groupeparima.com

 

 


News

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Groupe PARIMA Joins PBOA

2016-08-18

Pharma & Biopharma Outsourcing Association (PBOA), the trade association for CMOs and CDMOs, as a General Member.  Read the news release.

Groupe PARIMA Appoints Vice-President, Product Development

2016-05-11

Groupe PARIMA is pleased to announce the appointment of Alain Desjardins, PhD as VP of Product Development.
“Dr. Desjardins brings considerable experience in product development and process validation, as well as a breath of scientific expertise, which includes not only semi-solid and liquid drug products, but also solid and sterile dosage forms,” said, Dr. Cantin. “I am confident he will implement innovative development strategies that will enable us to fully leverage our extensive resources and long-standing expertise to further meet our clients’ evolving needs in the global market.”  A pharmaceutical industry veteran, Alain most recently served as the Director of Project Management at Groupe PARIMA. During the 20 years prior to that, he held Product Development positions of increasing responsibilities at Pharmascience, Valeant and Sandoz.  Alain holds a PhD degree in Chemistry from McGill University in Montreal. This appointment is a further commitment from Groupe PARIMA to expand its presence in Product Development for global markets. “As a world class CDMO provider, Groupe Parima is already is uniquely positioned to help its clients seize opportunities all over the world. Alain’s wealth of knowledge and expertise will enhance our already strong development position.”

Since 2013, Groupe PARIMA’s contract Product Development segment business has experienced exceptionally strong growth driven by both small biotech companies as well as large pharma customers. Our clients, located all around the world, seek Groupe PARIMA’s expertise in the development of topical products.  To support this significant increase in Product Development demand, Groupe PARIMA has invested heavily in the acquisition of new laboratory and scale-up equipment and tripled the Product Development headcount by hiring chemists, engineers and projects managers.
 

Groupe Parima will be at DCAT Week 2016

2016-03-07

Groupe Parima will be participating in DCAT week (New York City, March 14-17th), one largest gatherings in the world for pharmaceutical and related industries. To schedule a meeting with us at DCAT, please click on the following link (Meet at DCAT). We look forward to meeting you!

Come and Meet Us at CPhI Worldwide in Madrid

2015-09-28

Please come and meet us at CPhI Worldwide 2015  at the IFEMA - Feria de Madrid on October 13th to 15th. We will be available for meetings at your convenience during the event. To set up an appointment, use the following link (CPhI 2015) or contact us at bd@groupeparima.com. We look forward to meeting you.

Come and Meet Us at Contract Pharma 2015

2015-08-23

Please come and meet us at Contract Pharma 2015 Contracting and Outsourcing Conference and Tabletop Exhibition event at the Hyatt Regency in New Brunswick, NJ on September 17th and 18th. We will be at booth # 78 on September 17th and available for meetings at your convenience in NY/NJ during that entire week. To set up an appointment, use the following link (Contract Pharma 2015). We look forward to meeting you!

Groupe PARIMA Appoints President

2015-07-31

Groupe PARIMA announces today the appointment of Louis-David Cantin as President of the company. Since joining Groupe PARIMA in 2013, Mr. Cantin has been instrumental in leading the triple-digit growth of the Product Development business. In his new role, he will bring his 15 years of pharmaceutical R&D and business management experience to complete the transformation of Groupe PARIMA into a word class integrated pharmaceutical development and manufacturing organization.
 
Claude Mongrain, founder of Groupe PARIMA, will remain as CEO of the company. Mr. Mongrain will focus his activities on conducting business development throughout the world, establishing strategic partnerships and evaluating various growth opportunities.
 
Groupe PARIMA is a Development and Manufacturing Organization (CDMO) specialized in the development and manufacturing of pharmaceutical products as liquids, suspensions, semi-solids and sprays.  With licenses from Health Canada and the US-FDA, Groupe PARIMA manufactures and ships products to all five continents.  Groupe PARIMA clients range from small startup and virtual companies to global pharmaceutical companies located outside Canada.

Meet with us at 2015 BIO International Convention

2015-06-01

Groupe Parima will be participating in 2015 BIO International Convention (Philadelphia, June 15-18th), one largest gatherings in the world for biotechnology. To schedule a meeting with us at BIO, please click on the following link (Meet at BIO 2015) or use the BIO partnering platform. We look forward to seeing you!

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