H

REACH THE WORLD.

 

Groupe PARIMA

is a Contract Development and Manufacturing Organization (CDMO), established in 1994. Over the years, we have developed an expertise in the development and manufacturing of non-sterile liquids, suspensions and semi-solid drug products. We work hand-in-hand with our clients to customize our services to meet their needs. From full turn-key to highly collaborative development projects, we can adapt to fit your operational requirements. We have been favorably inspected by the EMA, TMMDA, FDA and Health Canada. We manufacture products for markets around the globe.

 

 


Product Development Services

PDS

Our team of dedicated project managers and of subject-matter-experts have successfully developed a wide range of products and dosage forms, supporting diverse regulatory approvals (IND, NDA, 505 (b) (2), ANDA). Groupe PARIMA can meet your product development and site-transfer needs based on the status of your project. Our experts in formulation development, scale-up process, analytical method development & validation and packaging, will see your product through initial development phases until completion of process validation. 

Expertise in formulation development

Liquids, Suspensions, Creams, Lotions, Gels, Ointments, Pastes, handling of low flash point products and processes

Different stages of activities

  • Basic formulation
    • De novo formulation
    • Reverse engineering
    • Equivalence to reference drug products
    • Raw material sourcing for cGMP Production
    • Effectiveness and stability of formulations
    • Identification of critical characteristics
    • Selection of packaging components
  • Process development
    • Laboratory, pilot, and cGMP clinical trial materials Commercial scale cGMP
    • Development and optimization using QbD
    • Documentation and reporting to support regulatory filings
    • Development of packaging process (primary and secondary)
    • Stability and transportation studies
  • Supply of clinical and pre-clinical batches
    • Small scale productions for pre-clinical studies
    • Supply of cGMP clinical material (Phases I-III)
    • Excess product stored on-site for future studies
    • Stability studies
    • Customized packaging and labeling
  • Commercial validation
    • Artwork preparation
    • Sourcing of all sales packaging material
    • Complete manufacturing, holding, packaging and cleaning validation
    • Stability studies

 

Commercial Manufacturing Services

CMS

Groupe PARIMA offers contract manufacturing and packaging services to customers throughout the world. We are currently manufacturing products for markets located on five continents, allowing our clients to have global reach. Further, our staff can provide you with a full turn-key service, from sourcing raw materials and packaging components to serialization and distribution of even the most challenging products. We can take care of your supply chain, providing you with a cost-effective option to confidently dedicate your resources to other priorities.

Currently, Groupe PARIMA produces a wide-range of business products, with the following applications:

  • Angina pectoris (oral spray)
  • Acne vulgaris (cleanser, towelette, frost)
  • Constipation (oral liquid)
  • Cough and fever treatments (oral liquid)
  • Dermatitis and eczema (cream, lotion, ointment)
  • Dry hands (lotion, cream)
  • Erectile dysfunction (cream)
  • Fungal Infections (liquid)
  • Headaches (oral liquid)
  • Hemorrhoids (cream)
  • Herpes simplex infection (ointment)
  • Joint inflammation (oral suspension)
  • Musculoskeletal pain (cream)
  • Sunscreen products (SPF 30-50 +, cream, lotion)



Manufacturing

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Our 67,000 square foot modern facility is equipped with a wide-range of manufacturing equipment that allows us to handle all kinds of semi-solids, liquids and suspensions.

Using several different manufacturing suites, we can manufacture your drug products on the following scales:

  • 5 kg to 2500 kg: Creams, Lotions, Gels, Ointments, High Viscosity Pastes and high-SPF sunscreen products
  • 5 kg to 4000 kg: liquids, syrups, suspensions
  • Fully jacketed tanks allow temperature control between 2 ºC and 95 ºC
  • Tanks are equipped with sweep, counter-sweep and Homogenizers
  • Secondary manufacturing equipment is available (eg, Lightnin Mixers, Rotosolver, Colloid Mills, APV)
  • Inert atmosphere, vacuum and yellow-light possible in most equipment and manufacturing suites

In addition to these capabilities, we have a dedicated explosion-proof manufacturing facility specifically designed to handle manufacturing of low-flash point of mixtures (e.g., high-alcohol gels and liquids).

  • 1D1 rated room
  • Inert gas blanketing
  • Amber lighting for light-sensitive products
  • Manufacturing volumes of 5 kg to 1600 kg

Packaging

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Groupe PARIMA has a dedicated packaging suite equipped with 12 different packaging lines to meet your needs for all types of primary and secondary packaging. Depending on projected annual volumes, we can offer different levels of automation to provide you with the most cost-effective options for your product.

  • Bottles and jars - plastic and glass
  • Pump Sprays
  • Metered-dose (Nasal and Sublingual)
  • Tubes - plastic, laminate and metal
  • Syringe (non-sterile applicators)
  • Sachets 
  • Towelettes 
  • Bags 
  • Bag-on valve
  • Airless Pumps

Analytical Services

AS

Our laboratory is fully equipped to perform all release and stability testing. From state-of-the-art LCMS analysis to microbiology and more routine physical tests, Groupe PARIMA can perform a wide-range of analysis to fit your needs. Our chromatography instruments are all powered by the Empower 3 software, and all analytical results are managed in our LIMS system.

Groupe PARIMA has on-site stability chambers to perform all typical ICH stability testing, including IV-B Zone and low temperature (2-8 ° C for cold-chain products) conditions.

Analytical chemistry equipment

  • Agilent and Waters HPLCs and UPLCs
  • Agilent GC with Head Space
  • Waters LCMS
  • IVRT (Franz cells) – (Hanson)
  • Microscope based particle size
  • Laser based particle sizing (Mastersizer 3000)
  • Laser based droplet size (nasal and oral sprays, Spraytech)
  • Agilent dissolution apparatus
  • IR and UV spectrometers
  • Viscometers
  • Microscope
  • Fully equipped for other physical tests

Microbiology Tests Performed On-Site

  • Total aerobic count (USP <61>)
  • Yeast and mold (USP <61>)
  • Specific organisms (USP <62>, USP<60>)
  • Microorganism identification
  • Antimicrobial effectiveness test (USP <51>)

Stability Conditions

  • Long-term (25 ° C / 60% RH)
  • Intermediate (30 ° C / 65% RH)
  • Accelerated (40 ° C / 75% RH)

IV-B area

  • 30 ° C / 75% RH

Cold-chain products

  • 2-8 ° C

About us

AT

COMPANY
 

Groupe PARIMA is a Contract Development and Manufacturing Organization (CDMO), established in 1994. For over 25 years, we have developed an expertise in the development and manufacturing of non-sterile liquids, suspensions and semi-solid drug products. We work hand-in-hand with our customers to customize our services to meet their needs. From full turn-key services to highly collaborative development projects, we can adapt to fit your operational requirements.

OUR CLIENTS
 

With products manufactured for markets located on all five continents, we have a global reach. Our client base ranges from start-up to global pharmaceutical companies headquartered around the globe. We have been favorably inspected by the EMA, TMMDA, FDA and Health Canada.

OUR MANAGEMENT TEAM
 


The management team is supported by a staff of professionals with a wide-range of expertise and experience including Chemists, Biochemists, Microbiologists, Engineers, and highly qualified operators.


Career

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We have numerous positions available in the following departments:
Operations, Quality Assurance, Product Development and Administration.

Click here for more information.


Please send your CV to this email.

info@groupeparima.com


Certifications

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FDA Registration Number: 3003773810
NDC Labeler Code: 65179
Health Canada Drug Establishment Licence: 100062-A
Licenced by Health Canada to Produce NPN and Homeopathic products
Generic Drug User Fee Amendment (GDUFA) Compliant
Licence from the Turkish Medicines and Medical Devices Agency, Ministry of Health, Republic of Turkey


Contact

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Groupe PARIMA inc.
4450 Rue Cousens
Saint-Laurent QC H4S 1X6
Canada

 



For general inquiries
+1.514.338.3780
info@groupeparima.com

New Business Projects Inquires +1.514.338.3780
bd@groupeparima.com

 

 


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